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The role of mitochondria in early-onset preeclampsia
(University of Missouri--Columbia, 2023)
[EMBARGOED UNTIL 12/1/2024] Placental mitochondrial dysfunction may play a role in the etiology of early-onset preeclampsia (EOPE). Mitochondrial function is impaired at term in placentas delivered from EOPE pregnancies, ...
Involvement of aberrant chromosome architecture and locus-specific vulnerability to DNA methylation epimutations in bovine large offspring syndrome
(University of Missouri--Columbia, 2022)
methylated regions; DMRs) observed in the syndrome only explain [less than] 4 percent of the gene misregulation in short range (the flanking 20,000 DNA bases from the DMR). Therefore, another goal of my dissertation research is to determine whether long...
An examination of influenza immunity in pigs and their role in assessing antiviral therapies for humans
(University of Missouri--Columbia, 2022)
The lung is dynamic barrier organ with a complex cell population. Pulmonary immune cells must balance an effective and tolerogenic response to keep homeostasis. Due to numerous similarities to the human respiratory system, ...
Discovery and phenotyping of the determinants and receptors of post-fertilization sperm mitophagy
(University of Missouri--Columbia, 2023)
[EMBARGOED UNTIL 12/1/2024] This thesis is concerned with two important aspects of sperm physiology -- mitochondrial health prior to fertilization and mitochondrial inheritance after fertilization. The factors and mechanisms ...
Improving the value of pigs with severe combined immunodeficiency through novel transplantation
(University of Missouri--Columbia, 2023)
[EMBARGOED UNTIL 12/1/2024] Continual rapid advances in biomedical research necessitate the efficient development of animal models that translate findings from preclinical studies into the clinics. Traditional animal models ...
Investigating sire fertility : the relationship between spermatozoa characteristics and early embryonic development
(University of Missouri--Columbia, 2022)
Early embryonic mortality in cattle occurs between days 1-27 of gestation and is one of the primary contributors to economic failure in the dairy industry. Specifically, by day 7 of gestation, up to 50 percent of all embryo ...
Applying deep learning technologies to discovery and characterization of genetic variants in animal genomes
(University of Missouri--Columbia, 2023)
[EMBARGOED UNTIL 12/1/2024] The scale of publicly available genomic data has rapidly expanded by an order of magnitude within the last decade. However, research with these aggregated public data requires minimizing the ...